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Protective effect of curcumin agains Source Food Chem Toxicol SO 2014 Jul 69C 182 201[PMIDT24751969]

Protective effect of curcumin agains Source Food Chem Toxicol SO 2014 Jul 69C 182 201[PMIDT24751969]

Protective effect of curcumin agains Source Food Chem Toxicol SO 2014 Jul 69C 182 201[PMIDT24751969]

Review

Protective effect of curcumin against heavy metals-induced liver

damage

Protective effect of curcumin agains Source Food Chem Toxicol SO 2014 Jul 69C 182 201[PMIDT24751969]

沙巴体育外围appWylly Ramsés García-Niño,JoséPedraza-Chaverrí⇑

Department of Biology,Faculty of Chemistry,National Autonomous University of Mexico (UNAM),University City,04510D.F.,Mexico

沙巴体育外围appa r t i c l e i n f o Article history:

沙巴体育外围appReceived 10February 2014Accepted 8April 2014

Available online 18April 2014Keywords:

沙巴体育外围appHepatoprotective Curcumin Nrf2

沙巴体育外围appHeavy metals Oxidative stress

Mitochondrial dysfunction

沙巴体育外围appa b s t r a c t

Occupational or environmental exposures to heavy metals produce several adverse health effects.The common mechanism determining their toxicity and carcinogenicity is the generation of oxidative stress that leads to hepatic damage.In addition,oxidative stress induced by metal exposure leads to the acti-vation of the nuclear factor (erythroid-derived 2)-like 2/Kelch-like ECH-associated protein 1/antioxidant response elements (Nrf2/Keap1/ARE)pathway.Since antioxidant and chelating agents are generally used for the treatment of heavy metals poisoning,this review is focused on the protective role of curcumin against liver injury induced by heavy metals.Curcumin has shown,in clinical and preclinical studies,numerous biological activities including therapeutic efficacy against various human diseases and anti-hepatotoxic effects against environmental or occupational toxins.Curcumin reduces the hepatotoxicity induced by arsenic,cadmium,chromium,copper,lead and mercury,prevents histological injury,lipid peroxidation and glutathione (GSH)depletion,maintains the liver antioxidant enzyme status and pro-tects against mitochondrial dysfunction.The preventive effect of curcumin on the noxious effects induced by heavy metals has been attributed to its scavenging and chelating properties,and/or to the ability to induce the Nrf2/Keap1/ARE pathway.However,additional research is needed in order to propose curcu-min as a potential protective agent against liver damage induced by heavy metals.

沙巴体育外围appÓ2014Elsevier Ltd.All rights reserved.

Contents 1.Introduction (183)

2.

沙巴体育外围appCurcumin ...........................................................................................................1842.1.Therapeutic potential ............................................................................................1842.2.Antioxidant properties ...........................................................................................1842.3.Anti-hepatotoxic properties .......................................................................................1863.

沙巴体育外围appArsenic hepatotoxicity .................................................................................................1873.1.Mechanism of action and Nrf2induction ............................................................................1873.2.Curcumin hepatoprotection .......................................................................................1874.

沙巴体育外围appCadmium hepatotoxicity ...............................................................................................1884.1.Mechanism of action and Nrf2induction ............................................................................1884.2.Curcumin hepatoprotection .......................................................................................1885.

Chromium hepatotoxicity ..............................................................................................1895.1.Mechanism of action and Nrf2induction ............................................................................1895.2.Curcumin hepatoprotection .......................................................................................1896.

Copper hepatotoxicity .................................................................................................1896.1.Mechanism of action and Nrf2induction ............................................................................1906.2.Curcumin hepatoprotection .......................................................................................1907.

Lead hepatotoxicity ...................................................................................................1907.1.Mechanism of action and Nrf2induction ............................................................................

190

http://chaletgabbro.com/doc/bbe715335ef7ba0d4b733b54.html/10.1016/j.fct.2014.04.016

0278-6915/Ó2014Elsevier Ltd.All rights reserved.

沙巴体育外围app⇑Corresponding author.Address:Faculty of Chemistry,Department of Biology,Laboratory 209,Building F,National Autonomous University of Mexico (UNAM),University City,04510,D.F.,Mexico.Tel./fax:+525556223878.

沙巴体育外围appE-mail address:pedraza@unam.mx (J.Pedraza-Chaverrí).